Dr Paul Edison

Dr Paul Edison is a Clinical Senior Lecturer in the Division of Brain Sciences at Imperial College London and an Honorary Professor at Cardiff University, Wales. He is also a Consultant Physician at Hammersmith Hospital, London. Dr Edison’s research has focused on neuroimaging with novel molecular probes using PET and magnetic resonance techniques for imaging pathophysiological changes associated with Alzheimers disease, Parkinson’s disease, and other neurodegenerative diseases. He has extensive experience in PET imaging in different neurodegenerative and neuroinflammatory conditions. Combined with his clinical expertise in different types of degenerative diseases and dementia, he has investigated the relationship between amyloid deposition, microglial activation, and glucose metabolism in different disorders, along with evaluating different transporters in the brain. His work in assessing microglial activation and amyloid load showed that both of these are increased in Alzheimers disease, and microglial activation correlates with cognition in late stage of the disease, while amyloid load does not correlate with cognition. He has also demonstrated that there are two peaks of microglial activation in Alzheimers trajectory. He was an MRC clinical research fellow before he became a HEFCE clinical senior lecturer. His work now focuses on neuroinflammation, and the interplay between inflammation and immunity in neurodegenerative and neuroinflammatory disease, and relating these with genetic information. He is also evaluating the methods of modulating inflammation and amyloid in Alzheimers disease, and the influence of cardio metabolic factors on the development of neurodegenerative diseases by means of clinical and pre-clinical studies. He leads the Imperial College Memory Research centre, and is the Chief Investigator of several imaging studies using PET and MRI, and heads multicentre studies evaluating novel treatment of Alzheimer’s and other neurodegenerative diseases. He also runs a memory clinic at Imperial College Healthcare NHS Trust.